Kamis, 06 Maret 2014

PDF⋙ Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences)

Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences)

Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences)

Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) PDF, ePub eBook D0wnl0ad

The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between DNA bending and indirect readout. Horvath lays out the fundamentals of protein recognition of single stranded DNA and single stranded RNA, and describes how they apply in a detailed analysis of telomere end binding proteins. Nucleic acids adopt more complex structures - Lilley describes the conformational properties of helical junctions, and how proteins recognize and cleave them. Because RNA readily folds due to the stabilizing role of its 2'-hydroxyl groups, Li discusses how proteins recognize different RNA folds, which include duplex RNA. With the fundamentals laid out, discussion turns to more specialized examples taken from important aspects of nucleic acid metabolism. Schroeder discusses how proteins chaperone RNA by rearranging its structure into a functional form. Berger and Dong discuss how topoisomerases alter the topology of DNA and relieve the superhelical tension introduced by other processes such as replication and transcription. Dyda and Hickman show how DNA transposes mediate genetic mobility and Van Duyne discusses how site-specific recombinases "cut" and "paste" DNA. Horton presents a comprehensive review of the structural families and chemical mechanisms of DNA nucleases, whereas Li in her discussion of RNA-protein recognition also covers RNA nucleases. Lastly, FerrÚ-D'AmarÚ shows how proteins recognize and modify RNA transcripts at specific sites. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons.

From reader reviews:

Brandy Greenawalt:

The reason why? Because this Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) is an unordinary book that the inside of the book waiting for you to snap that but latter it will surprise you with the secret that inside. Reading this book next to it was fantastic author who all write the book in such wonderful way makes the content within easier to understand, entertaining approach but still convey the meaning completely. So , it is good for you for not hesitating having this any longer or you going to regret it. This book will give you a lot of rewards than the other book get such as help improving your proficiency and your critical thinking technique. So , still want to hold off having that book? If I ended up you I will go to the book store hurriedly.


Ruby Chartrand:

Do you have something that you like such as book? The guide lovers usually prefer to decide on book like comic, small story and the biggest the first is novel. Now, why not trying Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) that give your fun preference will be satisfied by simply reading this book. Reading addiction all over the world can be said as the opportinity for people to know world considerably better then how they react in the direction of the world. It can't be stated constantly that reading routine only for the geeky individual but for all of you who wants to always be success person. So , for all you who want to start reading as your good habit, you could pick Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) become your personal starter.


Robert Wolfe:

You can obtain this Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) by browse the bookstore or Mall. Just simply viewing or reviewing it might to be your solve challenge if you get difficulties for your knowledge. Kinds of this e-book are various. Not only by written or printed but additionally can you enjoy this book by e-book. In the modern era like now, you just looking of your mobile phone and searching what their problem. Right now, choose your current ways to get more information about your guide. It is most important to arrange you to ultimately make your knowledge are still up-date. Let's try to choose correct ways for you.




Read Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) for online ebook

Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) Free PDF d0wnl0ad, audio books, books to read, good books to read, cheap books, good books, online books, books online, book reviews epub, read books online, books to read online, online library, greatbooks to read, PDF best books to read, top books to read Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) books to read online.

Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) Doc

Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) Mobipocket
Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) EPub

Tidak ada komentar:

Posting Komentar